Municipalities are facing a growing problem of how to safely dispose off their wastes. Municipalsolid waste (MSW) is waste from households, commercial centres, institutions (school, offices).Composting is used to reduce huge pile of biodegradable MSW and convert it into value addedproduct like manure and biogas. Inorganic fertilizer such as NPK also exerts strong influence onplant growth, development and yield. Two year experiments were conducted in the Teaching andResearch Farm of Department of Crop Science, Faculty of Agriculture, University of Nigeria,Nsukka to determine the response of maize to MSW compost and NPK fertilizer application. A 4 x 4factorial experiment in Randomized Complete Block Design (RCBD) with three replications was used for the study.