The study seeks to empirically analyse the impact of exchange rate depreciation on foreign direct investment in Nigeria from 1981 -2014. The data for the research study was extracted from CBN statistically bulletin volume 25, 2014 edition. The methodology is ordinary least square were foreign direct investment was regressed on Exchange Rate, Real Gross Domestic Product and Openness of the economy. Some econometrics test were conducted such as the unit Root, Contegration and Vector Autoregressive Model. The unit root result shows that none of the variables were stationary at level, but at first differencing they all became stationary. The contegration result shows that there is no long run relationship among the variables. The vector autoregressive model shows that exchange rate had an impact on economic growth. It is on this note that the researcher recommends amongst others that: policy makers should continue on the part of floating exchange rate policy to enable our domestic currency assume its proper level among the committee of world currencies, for purpose of establishing appreciation in the exchange rate of the naira, to ensure effective economic planning and sustainable growth and development.