Kaizen has become global activity spread to multi companies and their employees including manufacturing sector. It is a continuous development in quality of products or services, continuous improvement in productivity, cost/waste reduction, better safety and employee’s satisfaction. However proliferation of kaizen in Africa is still very small due to the limited number of players who bring in the practice. Thus, this research examined the determinants for effectiveness of kaizen implementation in Kadisco Paints and Adhesive Share Company. To achieve the aim of this study, data was collected through questionnaire from a sample of 117 employees of the company selected using simple random sampling method. The study employed the statistical methods mean, standard deviation, correlation, and multiple regression analysis to analyze the data. The regression results showed all independent factors significantly explain 82% of the variations in effectiveness of kaizen implementation in Kadisco Paints and Adhesive Share Company. It was found that top management, methodological or tools and perception towards kaizen implementation factors were found to be the determinants for effectiveness of kaizen implementation in Kadisco Paints and Adhesive Share Company with p-value <0.01. The study also confirmed that top management factor was the most important factor with the beta value 0.396 to have positive effect on effectiveness of kaizen implementation, followed by perception towards kaizen implementation factor with the beta value 0.336.Therefore, the study concluded that that top management, methodologies or tools and perception towards kaizen implementation factors have positive and significant effect on for effectiveness of kaizen implementation. Thus, result show the company shall revise all top management commitment and performance, methodologies or tools and perception of employees towards kaizen implementation for effectiveness of kaizen implementation.