This study examined the effect of government expenditure on economic growth and development inNigeria for the period of 1990–2012. Time series data for twenty-two years were sourced from secondary data such as the CBN statistical bulletin and other relevant publications using the desk survey method. Ordinary Least Square (OLS) multiple regression technique was used to estimate the effect of government expenditure on economic growth and development in Nigeria. Gross Domestic Product, proxy for economic growth and development was adopted as the dependent variable whileTotal Recurrent Expenditure and Total Capital Expenditure constitute the independent variables.The results of this study showed that the Federal Government Expenditure on Education, Health,General Administration, and Road Construction for the period; 1990–2012 has a positive and significant impact on the economic growth and development of Nigeria. The result further showed that government expenditure on Agriculture for the period investigated had been undulating and thisresulted in an inverse relationship with GPD. It therefore follows that Government should put inplace adequate control measures/techniques to ensure that funds allocated to the different sectorsof the economy especially the agricultural sector are judiciously used for the projects for which theyare allocated.