This study was carried out to investigate the comparative study of the effect of fresh stem juice and aqueous stem juice extract of costus afer (bush cane) on the histomorphology of the stomach of Paracetamol treated albino wistar rats. The effect of fresh stem juice extract of Costus afer on cytohistomorphology of the kidney in aspirin-treated Wistar rats was evaluated. 25 rats weighing 150–180 g used for the study were divided into five groups with five rats in each group. Group 1 served as control while Group 2 was administered 150 mg/kg bw of aspirin daily for 28 days, Group 3 received 67.08 mg/kg bw of the extract of C. afer for 28 days, Group 4 was administered 150 mg/kg of aspirin and 67.08 mg/kg of the extract for 28 days while Group 5 was administered 150 mg/kg of aspirin for 14 days and then 67.08 mg/kg of the extract for another 14 days. Kidneys were harvested for histological studies. The results revealed that Group 1 showed normal histological features, Group 2 showed tubular necrosis, collapsed urinary space, and distorted glomerulus, Group 3 presented near normal features, Group 4 showed enlarged urinary space, inflamed tubular cells and reduced podocytes in the glomerulus compared to Group 2, and Group 5 revealed regeneration of cellular features already destroyed by aspirin. In conclusion, fresh stem juice extract of C. afer has ameliorative and protective potentials on nephrotoxicity of aspirin in albino Wistar rats.