This study was carried out to investigate the problems militating against effective teaching and learning of Christian Religious Studies in junior secondary schools in Oji-River Local Government Area of Enugu State. To achieve this objective, three research questions and two research hypotheses were formulated to guide the study. The data was collected from primary sources. The primary data were collected with the help of a well-structured questionnaire of two sections administered to teachers of selected secondary schools in Oji-River Local Government Area. The collected data were analyzed with tables and simple percentages to analyze the research questions while Chi-square statistical tool was used to test research hypotheses. The study reveals that there are problems facing teachers in teaching Christian religious studies in Nigeria secondary schools in Oji-River Local Government Area and there are challenges to effective implementation of Christian religious studies curriculum in secondary schools. The study concluded with some recommendations that there is need for the school managers to not only organize, but encourage CRS teachers to attend workshops and seminars because the job of moulding human behavior is dynamic; hence regular attendance to seminars will equip them, with new approaches and methods for effective implementation of CRS curriculum among students.