Hepatotoxicity is defined as a chemical driven liver damage. Carbon tetrachloride is used as a hepatotoxic agent in animal research work to study the hepato-curative agent in plants and other compounds. The present work was aimed to study the hepatoprotective effect of citrus limon on carbon tetrachloride induced hepatotoxicity. Toxicological studies and experimental extract treatment study was conducted. In the extract treatment group, the animals were divided into four Groups of A,B,C and D. All animal study group after post treatment by a midline incision samples of the livers of the animals were and stained with hematoxylin and eosin and then examined microscopically. Histological examination of Group A (control group) showed the normal histological structure of hepatic lobule and preserved hepatic architecture, Group B (Negative control) showed focal hepatic necrosis associated with leucocytic cell infiltration and apoptosis of hepatocyctes, Group C (6.1ml/daily) showed cystically dilated central vein, pyknotic nuclei and pleomorphic nuclei, with mild binucleated hepatocytes indicative of kuffer cell activation and Group D (9.9ml/daily) showed pleomorphism, clustered hepatocytes, cystic spaces amidst a slight inflammatory response. In the toxicological study group, the animals were divided into three groups. Group1 which received 7.2ml/100g of extract had zero mortality, Group 2 received 9.5ml/100g of extract had half mortality of animal group and was assumed as LD50 while group 3 which received 12.6ml/100g of extract had 100% mortality and was accepted at the LD100. In conclusion, the results of this study demonstrate that Citrus limon juice extract was effective for the treatment of CCl4-induced hepatic damage in rats. Further research was recommended to finding specific constituent(s) responsible for hepatoprotective activity and also to discover the exact mechanism of action.