A screen house experiment was conducted in the Botanical Garden of Plant Science and Biotechnology Department, University of Nigeria, Nsukka to assess the effects of refuse dump compost and poultry manure on the growth and yield of Amaranthus hybridus. The accumulation of heavy metals (Hg, Cu, Cd, Zn, Pb and Cr) in the leaves, stems, roots and seeds of A. hybridus at the end of the experiment were also assessed. The treatment comprised Treatment A (garden soil and river sand in the ratio of 3:1 as control); Treatment B (garden soil, refuse dump compost and river sand in the ratio of 3:2:1); and Treatment C (garden soil, poultry manure and river sand in the ratio of 3:2:1). The treatments were replicated nine times in a completely randomized design with five experimental units. A. hybridus was raised in a nursery and transplanted at 3 weeks after planting. The resulting data was subjected to ANOVA and means separated using DNMRT at P ≤ 0.05. The results of the study showed that application of Treatment C produced the highest mean plant height (88.00±5.13 cm), number orf leaves (55.80±2.62), leaf area (140.89±6.92 cm2), fresh weight of leaves, stems, roots and seeds (52.47±1.42 g, 41.57±2.10 g, 10.19±0.41 g and 0.24±0.10 g respectively); and dry weight of leaves, stems, roots and seeds (5.36±2.21 g, 3.96±1.63 g, 1.78±0.74 g and 0.19±0.08 g respectively).