This study was carried out to examine the impact of development bank of Nigeria on the growth of Small and medium Scale Enterprises in Akwa Ibom State. To achieve this objective, three research questions and two research hypotheses were formulated to guide this study. The data collected were analyzed using simple percentages and tables to analyze research questions and Chi-square statistical tool was used for testing of research hypotheses using Statistical Package for Social Sciences (SPSS) software. A structured questionnaire was used as the major instrument for data collection from the respondents in Small and medium Scale Enterprises in Akwa Ibom State. After careful analysis of the data, the following findings were revealed that; there is a significant difference between the impact of commercial banks in promoting Small and Medium Scale Enterprises in Ikono Local Government Area of Akwa Ibom State and there are challenges facing the growth of Small and medium Scale Enterprises in Akwa Ibom State. The study was concluded with some recommendations that adequate capital should be provided to small and medium scale enterprises in Akwa Ibom State and sdequate savings should be made both in personal/internal proceeds of the operators of the mall and medium scale enterprises.