Waterborne diseases have been a major health issue globally because of the burden it places on man. As a result of this, the present study therefore aimed at analysing the spatio-temporal pattern of waterborne diseases, using Kwara State as a case study. Primary and secondary data were obtained from questionnaire survey, Focus Group Discussions, interviews and published and unpublished works. Multi-stage sampling method was adopted in this study. Four stage sampling method was adopted in the selection of sample size. National Population Commission (1991) estimated that the mean household for each settlement in Kwara State (as at 1991 population census) was 4.7 for the selected settlements. In all, a total of 353 households were sampled across the three senatorial districts. Kwara South Senatorial district has the highest number of households of 127, while Kwara North and Central Senatorial districts have 118 and 108 respectively.