Abstract
It is necessary to employ powerful strategies to screen and to identify new genetic loci involved in the regulation of toxicity of environmental toxicants or stresses in nematodes. We here introduced the usefulness of transcriptomic analysis, proteomic analysis, forward genetics, and reverse genetics in screening and in identifying new genetic loci involved in the regulation of toxicity of environmental toxicants or stresses. Meanwhile, we discussed the related limitations for these strategies in nematodes.