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PROJECT TOPIC: EFFECT OF HAEMOGLOBIN GENOTYPE ON EXERCISE TOLERANCE

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ABSTRACT The haemoglobin genotypes of 100 university student between the ages of 18-25 years were determined by cellulose acetate membrane (CAM) electrophoresis. There were 50 HBAA persons (25 males and 25 females) and 50 HBAS persons (25 males and 25 female). The exercise tolerance between the two genotype were then compared. Exercise was carried out on a bicycle ergometer and readings were achieved by a spirometer and keymograph. Exercise tolerance was determined by respiratory rate. There was a significant difference in exercise tolerance between HBAA persons and HBAS persons. HBAA individuals have a significantly higher exercise tolerance than their HBAS counterparts (p< 0.05). This suggests that HBAA persons may have a better perfo

CHAPTER ONE

1.1 HAEMOGLOBIN GENETYPE: There are 3 main haemoglobin genotypes found in Nigeria. These are Hb AA, Hb As and Hb SS. Haemoglobin AA genotype represents the normal adult haemoglobin. Haemoglobin as and Haemoglobin SS genotypes are known as sickle cell trait and sickle cell anaemia respectively. The basis anomaly underlying both Hb AS and Hb SS genotypes is the presence of an abnormal haemoglobin, known as haemoglobin – S. in those with the anaemia all the haemoglobin eg (SS). In those with the trait the haemoglobin – s has a proportion of about 30 – 40%, the remainder being normal haemoglobin I e heterozygous, which involves the combination of a normal haemoglobin with the variant haemoglobin eg AS.



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