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PROJECT TOPIC: TO EVALUATE RATIONALE USE OF NONSTEROIDAL ANTI-INFLAMMATORY DRUGS (NSAIDs) IN ILORIN METROPOLIS

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CHAPTER ONE

1.1 INTRODUCTION

NONSTEROIDAL ANTI-INFLAMMATORY DRUGS (NSAIDS) are medications used to relieve pain, fever and inflammation and they include a large group of anti-inflammatory agents that work by inhibiting the production of prostaglandins. Nonsteroidal anti-inflammatory drugs (NSAIDs) also represent diverse group of drug with analgesic property and most frequently prescribed drug globally. They represent the first  choice  of  drug  with  well demonstrated  efficiency  for the  pain  management primarily  musculoskeletal  disorder  and osteoarthritis to treat mild to moderate pain. Although its serious toxicity related to Gastro intestinal tract its choice in this category of its choice (Gul and Ayub, 2014).

There is overwhelming evidence linking chronic nonselective NSAID (including aspirin) use to a variety of Gastrointestinal (GI) tract injuries.  Age is a significant risk factor for NSAID-induced GI events; indeed, patients above 75 years of age carry the highest risk and are similar in this respect to patients with a history of peptic ulcer (Beradi and Welage, 2005)

People desire to take responsibility for their own health care management. Many do so via  self‑medication. Self‑medication is defined as the use of over‑the‑counter (OTC) drugs without consulting a professional health care practitioner. Self‑medication involves acquiring medication without  a prescription, resubmitting an old prescription to  procure medication, sharing medications with others, or utilizing a medication that is already available in the residence. Several governmental organizations developed policies to encourage self‑care for minor  illnesses, reclassifying many drugs as nonprescription  medications instead of prescription‑only medications,  allowing the drugs to be administered by patients  without a prescription. (Saeed et al, 2015) and could also be described as Medication  that  is  taken  on patient's own initiative or on advice of a pharmacist or lay  person(Neha et al, 2013)


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