CHAPTER ONE

INTRODUCTION

Bleeding disorder affects 1 in 1000 men and women globally (Skinner 2012) with haemophilia being the most well-known inherited bleeding disorder, although it is relatively rare and affect mostly males. Platelet disorder is the most common cause of bleeding disorder and usually acquired rather than inherited, but the most common inherited bleeding disorder in America is vonWillebrand disease and it affects both male and female (America Society of Haematology 2013).

 World Federation of Haemophilia (WFH) estimates that the prevalence of haemophilia worldwide is 105 and 28 per million males of haemophilia A and B respectively, with a global population of 6 billion this would give a prevalence of about 315,000 and 84,000 persons living with haemophilia (PLWH) A and B respectively (O’Mahony et al 2005). Data collected among 84 countries showed that about 115,000 persons has haemophilia which means that about 70% of PLWH remain undiagnosed and untreated mostly in developing countries including Nigeria (O’Mahony et al 2005). Study in Indian reported 14, 718 persons with bleeding disorder and 78.7% of them have haemophilia A (WFH 2013). Prevalence of haemophilia in Senegal in West Africa showed 2.3 per 100,000 male births (Diop et al 2014), while the incidence of haemophilia A and vonWillebrand vWD in South West Nigeria is 1.64% (Fakunle et al 2007).

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