This study was on impact of personality traits on interpersonal dependence among undergraduates in Ghana. The total population for the study is 200 students of University of Accra, Ghana. The researcher used questionnaires as the instrument for the data collection. Descriptive Survey research design was adopted for this study. A total of 133 respondents made final year students, year four students, year three students and year two students were used for the study. The data collected were presented in tables and analyzed using simple percentages and frequencies.