This study was conducted to assess the relationship between fake drug (FD) use and people’s attitude towards healthcare delivery system (HCDS). Participants (n = 103) were both healthcare providers (56) and consumers (47). 36 were males and 67 were females above eighteen years. They were selected through a random sampling technique. The mean ages were 37.2, 34.2 and 42.8 for all the participants, female participants and male participants respectively. All testing took place in Onitsha General Hospital, Community Pharmacies, medical Laboratories and classroom environments in Onitsha urban. Results revealed significant relationships (r = 0.6, p < 0.05). People’s attitude (selection, organization, and interpretation of health related information to form a meaningful picture of their health care needs) were considerably affected by the use of FD in HCDS.