Obesity is a popular health problem in the world, characterized by a metabolic disorder such as arteriosclerosis, hyperlipidemia, type 2 diabetes mellitus and cardiovascular disease. This study is carried out to determine the effect of Tetracarpidium conophorum nut extract on serum lipid profile of Monosodium Glutamate induced obesity in rats. Twenty five (25) rats, 15 females and 10 males were obtained from the animal house of the Department of Biochemistry, University of Calabar. The animals were divided and cohabited in five well ventilated cages in the ratio of 3:2 females to males respectively. Obesity was induced in the pups by intravenous administration 4mg/kg body weight of MSG on day 2, 4, 6, 8 and 10. The animal were confirmed obese using their BMI after 12 weeks. The rats were assigned into 6 groups, 7 rats per group. Group 1 serve as normal control and was treated with normal saline, group 2 to 6 were administered with the following, standard anti-obesity drug (Orlistat 5.14mg/kg body weight), whole extract of Tetracarpidium conophorum (2g/kgbw), ethyl acetate extract of Tetracarpidium conophorum (2g/kg BW), respectively.