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MEDICINE AND SURGERY PROJECT TOPICS AND RESEARCH MATERIALS


  • 1. NUTRITIONAL KNOWLEDGE AND PRACTICE AMONG EXPECTANT MOTHERS

    » CHAPTER ONE INTRODUCTION 1.1 BACKGROUND TO THE STUDY Nutritional knowledge has been proven to play a very vital role in adopting optimal nutrition practices in the health of every expectant mother. As a matter of fact, health and nutritional status of the population of a nation is an important indicator of development of the country. A nutrition survey carried out in India observed that the nutrit...Continue Reading »

    50 pages |  95 engagements | 

  • 2. ROLE OF PERSONALITY TRAITS, PHYSICAL ATTRACTIVENESS AND GENDER ON SEXUAL HARASSM...

    » ABSTRACT This study examined the role of personality traits, physical attractiveness and gender on sexual harassment. A total of 300 participants comprising of 200 females and 100 males were all used for the study. The participants were students of Ebonyi state university and school of health technology Ezzamgbo. A 28 item Eysenck personality questionnaire of yes or no options were used to measure...Continue Reading »

    50 pages |  82 engagements | 

  • 3. PENTOSAN POLYSULFATE TREATMENT OF MUCOPOLYSACCHARIDOSIS TYPE IIIA MICE

    » Abstract Overall Goal: This study was designed to evaluate the impact of pentosan polysulfate (PPS) treatment on mice with mucopolysaccharidosis (MPS) type IIIA (Sanfilippo A syndrome; OMIM 252900). Protocol: Three groups of MPS IIIA mice were evaluated: 1 week old mice treated with subcutaneous (subQ) PPS at 25 mg/kg once weekly for 31 weeks (group 1); 5 month old mice treated with subQ PPS once ...Continue Reading »

    50 pages |  72 engagements | 

  • 4. REVERSIBLE CEREBRAL WHITE MATTER ABNORMALITIES IN HOMOCYSTINURIA

    » Abstract Striking MRI brain changes resembling leukoencephalopathy are rarely seen in classical homocystinuria. Our case suggests that reversible white matter changes (WMC) are linked to elevated plasma methionine levels arising during treatment. A 6 year old boy with learning difficulties and a normal MRI brain scan was diagnosed with homocystinuria (initial total homocysteine 344 μmol/L and m...Continue Reading »

    50 pages |  80 engagements | 

  • 5. ESTROGEN RECEPTOR-MEDIATED GENE TRANSCRIPTION AND CISTROME

    » Abstract The discovery of the estrogen receptor 60 years ago radically transformed the field of hormonal signaling and led to the recognition of ER as a prototype nuclear receptor that primarily functions as a transcription factor. In this chapter, we will first describe the conserved domain architecture of ER and its regulation through various modifications by diverse intracellular pathways. We w...Continue Reading »

    50 pages |  87 engagements | 

  • 6. SPONTANEOUS THROMBOSIS OF THE MAIN DRAINING VEINS REVEALING AN UNRUPTURED BRAIN ...

    » Abstract A case of AVM was presented and surgical details presented and discussed....Continue Reading »

    50 pages |  76 engagements | 

  • 7. STRATEGIES TO SCREEN AND TO IDENTIFY NEW GENETIC LOCI INVOLVED IN THE REGULATION...

    » Abstract It is necessary to employ powerful strategies to screen and to identify new genetic loci involved in the regulation of toxicity of environmental toxicants or stresses in nematodes. We here introduced the usefulness of transcriptomic analysis, proteomic analysis, forward genetics, and reverse genetics in screening and in identifying new genetic loci involved in the regulation of toxicity o...Continue Reading »

    50 pages |  74 engagements | 

  • 8. SEVERE LEUKOENCEPHALOPATHY WITH CLINICAL RECOVERY CAUSED BY RECESSIVE BOLA3 MUTA...

    » Abstract Aim: To identify the genetic aetiology of a distinct leukoencephalopathy causing acute neurological regression in infancy with apparently complete clinical recovery. Methods: We performed trio whole genome sequencing (WGS) to determine the genetic basis of the disorder. Mitochondrial function analysis in cultured patient fibroblasts was undertaken to confirm the pathogenicity of candidate...Continue Reading »

    50 pages |  66 engagements | 

  • 9. METABOLOMICS PROFILE IN ABAT DEFICIENCY PRE- AND POST-TREATMENT

    » Abstract Metabolomic profiling is an emerging technology in the clinical setting with immediate diagnostic potential for the population of patients with Inborn Errors of Metabolism. We present the metabolomics profile of two ABAT deficiency patients both pre and posttreatment with flumazenil. ABAT deficiency, also known as GABA transaminase deficiency, is caused by recessive mutations in the gene ...Continue Reading »

    50 pages |  61 engagements | 

  • 10. SCREENING FOR NIEMANN-PICK TYPE C DISEASE IN A MEMORY CLINIC COHORT

    » Abstract Niemann Pick type C disease (NPC) is a neurovisceral lysosomal storage disorder with a heterogeneous phenotype including ataxia, cognitive impairment, impairment of vertical saccades, and psychiatric symptoms, among many others. Based on clinical, genetic, and biomarker findings, recent guidelines put forward a screening for atypical and oligosymptomatic forms of NPC in clinical niches wi...Continue Reading »

    50 pages |  75 engagements | 

  • 11. ESTROGEN RECEPTOR AND BREAST CANCER: A HISTORICAL PERSPECTIVE

    » Abstract Sir George Beatson proposed a connection between breast cancer and ovary more than a century ago. It took several decades to the discovery of hormone estrogen and a few more decades when Elwood Jensen announced the discovery of estrogen receptor. His work led to our understanding of how hormones control target gene transcription via their receptors. Several laboratories made major contrib...Continue Reading »

    50 pages |  65 engagements | 

  • 12. ENZYME REPLACEMENT THERAPY DURING PREGNANCY IN FABRY PATIENTS

    » Abstract Fabry disease (FD) is an X linked, lysosomal storage disease. Mutations in the gene coding for alpha galactosidase A lead to globotriaosylceramide (Gb 3) accumulation in lysosomes and in placenta and umbilical cord. Impact of FD and treatment with enzyme replacement (ERT) on foetal development is undisclosed. A 38 year old primigravida with FD (G85N) is reported. She has 50% reduced alpha...Continue Reading »

    50 pages |  75 engagements | 

  • 13. ALTERNATIVE METHODS FOR DEVELOPMENTAL TOXICITY TESTING USING MOUSE ESCS

    » Abstract Development of an organism is accompanied by rapid and complex changes within a relatively short period, and embryotoxic chemicals administered to a mother during pregnancy can result in persistent lesions, general growth retardation, or delayed organ growth. In vitro toxicity tests are useful for evaluating the safety or hazards of small quantities of chemicals. Since cell death and inhi...Continue Reading »

    50 pages |  55 engagements | 

  • 14. EMERGING THERAPEUTIC APPROACHES TO OVERCOME BREAST CANCER ENDOCRINE RESISTANCE

    » Abstract Antiestrogen therapies have been a staple treatment option for estrogen receptor (ER) positive breast cancer patients for many decades, but resistance remains a major obstacle for continued successful treatment. In this chapter, we will discuss the preclinical and clinical research advancement in the development of novel strategies to overcome breast cancer endocrine resistance. We will f...Continue Reading »

    50 pages |  56 engagements | 

  • 15. ROLE OF CEREBRAL VENOUS SYSTEM IN TRAUMATIC BRAIN INJURY

    » Abstract Traumatic brain injury (TBI) is one of the most prevalent causes of neurological dysfunction, leading to substantial economic and social burdens worldwide. The brain edema, including cytotoxic and vascular brain edema, is one of the most important hallmarks of TBI. Brain edema induces an increase in intracranial pressure (ICP), resulting in decreased cerebral vascular perfusion and cerebr...Continue Reading »

    50 pages |  64 engagements | 

  • 16. ANAEMIA AND PARASITIC INFESTATIONS AMONG SCHOOL CHILDREN LIVING IN URBAN SLUMS ...

    » SUMMARY Anaemia is a public health problem that affects about 2 billion people worldwide. It is highly prevalent in developing countries with its prevalence; three to four times higher than that of developed countries as 53% school age children estimated to be suffering from anaemia. In Nigeria, the prevalence ranges from 38.6% in Edo State to 82.6% in Abia State. The consequences include cognitiv...Continue Reading »

    50 pages |  199 engagements | 

  • 17. ASSESSMENT OF POST-ABORTION CARE SERVICES IN PUBLIC HEALTH FACILITIES IN BAUCHI ...

    » SUMMARY Worldwide, an estimated five million women are hospitalized each year for treatment of abortion related complications, such as hemorrhage and sepsis. Almost all abortion related deaths occur in developing countries.2These deaths are highest in Africa, where there were an estimated 650 deaths per 100,000 unsafe abortions in 2003, compared with 10 per 100,000 in developed regions. African wo...Continue Reading »

    50 pages |  71 engagements | 

  • 18. KNOWLEDGE, PERCEPTION, PRACTICES AND SOURCES OF INFORMATION ON IMMUNIZATION AMON...

    » SUMMARY Immunization is one of the safest and most effective interventions to prevent disease and early child death. Although, about three quarters of the world‘s child population is reached with the required vaccines, only half of the children in Sub Saharan Africa get access to basic immunization. In Nigeria, only 10% of children in the North West geographical region are fully immunized co...Continue Reading »

    50 pages |  74 engagements | 

  • 19. ASSESSMENT OF AWARENESS AND ATTITUDE OF STUDENTS TOWARDS RISKS ASSOCIATED WITH M...

    » ABSTRACT Awareness is knowing that something exists and attitude is the way people behave towards something that shows how they think and feel concerning it. Medical X ray investigation is an indispensable arm of modern medicine that uses X ray for diagnosis and management of diseases. It is one of the most powerful medical imaging tool and the second most commonly used medical test after medical ...Continue Reading »

    51 pages |  118 engagements | 

  • 20. ASSESSMENT OF AWARENESS OF RADIATION EMISSION FROM MICROWAVE OVEN AMONG THE USER...

    » TABLE OF CONTENT Title Page i Approval Page ii Certification iii Dedication iv Acknowledgement v Abstract vi Table of Contents vii List of Tables ix List of Figures x CHAPTER ONE: INTRODUCTION 1.1 Background of Study 1 1.2 Statement of Problem 3 1.3 Objectives of the Study 3 1.4 Significance of the Study 4 1.5 Scope of Study 4 1.6 Literature Review 4 CHAPTER TWO: THEORETICAL BASE OF STUDY 2.1 Orig...Continue Reading »

    51 pages |  107 engagements | 

. ABSTRACT, Proposals, Literature Reviews, Aims & Objectives, Methodology, Surveys & Implementations