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» CHAPTER ONE INTRODUCTION 1.1 Background of Study Epidemiological studies have consistently identified an important and independent link between high blood pressure and various disorders especially coronary heart disease, stroke, congestive heart failure and impaired renal function. Despite the fact that systolic and diastolic blood pressures have been constantly identified as independent risk fact...Continue Reading »
50 pages | 434 engagements |
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» CHAPTER ONE 1.0 INTRODUCTION 1.1 BACKGROUND Radioactivity is the process by which a nucleus of an unstable atom losses energy by emitting particle of ionizing radiation. It is spontaneous emission of ionizing radiation as a consequence of nuclear reaction, or directly from the breakdown of an unstable nucleus. Materials that spontaneously emit these kinds of radiation include energetic alpha parti...Continue Reading »
50 pages | 318 engagements |
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» CHAPTER ONE INTRODUCTION Background of the Study Primary Education is the first formal Education level. It is the education given in institutions for children aged six to eleven plus. This level of education has among its goals the inculcation of permanent literacy and numeracy and the ability to communicate effectively (Federal Republic of Nigeria, 2004:14). At this level of education, the medium...Continue Reading »
50 pages | 554 engagements |
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» Okobiah (2003) stated that the architectural space, light, temperature, sound, furniture constitute the physical environment of the classroom. Vosko and Humstra (1998) identified the idea of physical learning environment to include anthropometry, ergonomics, proximics and synaesthetics. Anthropometry deals with design of furniture, equipment and space that will meet the learning needs of the stude...Continue Reading »
50 pages | 471 engagements |
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» CHAPTER ONE 1.0 INTRODUCTION 1.1 Background to the study ‘Today’s children are tomorrow’s leaders’. This slogan is raising a massive wave of concern throughout the world. However, children all over the world are deprived of many facilities. Children need various types of support ranging from those things necessary for survival, such as food, adequate nutrition and health ca...Continue Reading »
50 pages | -1 engagements |
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» ABSTRACT An epidemic free environment enhances the health status of all citizens in the community. The passive disease surveillance and notification systems occasioned by haphazard patient records management practices in the health facilities have led to devastating consequences on epidemic control in Osun State. This is why a sustainable epidemic controldepends on the extent to which patient reco...Continue Reading »
50 pages | 481 engagements |
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» CHAPTER ONE 1.0 INTRODUCTION The human resources crisis coupled with poor performance of health workers in the health sector in low and middle income countries (LMICs) like Tanzania, is receiving increased global attention [1]. This has resulted into policymakers and planners realizing that it is simply not possible to achieve the Millennium Development Goals (MDGs) if health workers’ availa...Continue Reading »
50 pages | 471 engagements |
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» CHAPTER ONE INTRODUCTION 1.1 Background to the study The English word “obesity” derives, from the Latin word obesus meaning ‘fat’ or plump. The first English use of the word was made in 1651 in Noah Bigg’s medical book ‘metaeotechnia medicinae praxeos’ (Mckeigne, 1996). Clinical evidence of obesity can be dated as far back as Greece Roman times but little ...Continue Reading »
50 pages | 451 engagements |
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» CHAPTER ONE 1.0 INTRODUCTION 1.1 Background to the Study Iodine is an essential mineral required by the body to synthesize thyroid hormones (thyroxine and triiodothyronine). The most important of which is thyroxine, a metabolism regulating substance (Kennedy, Nantel & Shetty,2003). The trace element (iodine) is an essential nutrient for human growth and development. The daily recommended intak...Continue Reading »
50 pages | 584 engagements |
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» CHAPTER ONE INTRODUCTION 1.1 BACKGROUND TO THE STUDY Nutritional knowledge has been proven to play a very vital role in adopting optimal nutrition practices in the health of every expectant mother. As a matter of fact, health and nutritional status of the population of a nation is an important indicator of development of the country. A nutrition survey carried out in India observed that the nutrit...Continue Reading »
50 pages | 745 engagements |
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» ABSTRACT This study examined the role of personality traits, physical attractiveness and gender on sexual harassment. A total of 300 participants comprising of 200 females and 100 males were all used for the study. The participants were students of Ebonyi state university and school of health technology Ezzamgbo. A 28 item Eysenck personality questionnaire of yes or no options were used to measure...Continue Reading »
50 pages | 576 engagements |
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» Abstract Overall Goal: This study was designed to evaluate the impact of pentosan polysulfate (PPS) treatment on mice with mucopolysaccharidosis (MPS) type IIIA (Sanfilippo A syndrome; OMIM 252900). Protocol: Three groups of MPS IIIA mice were evaluated: 1 week old mice treated with subcutaneous (subQ) PPS at 25 mg/kg once weekly for 31 weeks (group 1); 5 month old mice treated with subQ PPS once ...Continue Reading »
50 pages | 520 engagements |
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» Abstract Striking MRI brain changes resembling leukoencephalopathy are rarely seen in classical homocystinuria. Our case suggests that reversible white matter changes (WMC) are linked to elevated plasma methionine levels arising during treatment. A 6 year old boy with learning difficulties and a normal MRI brain scan was diagnosed with homocystinuria (initial total homocysteine 344 μmol/L and m...Continue Reading »
50 pages | 562 engagements |
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» Abstract The discovery of the estrogen receptor 60 years ago radically transformed the field of hormonal signaling and led to the recognition of ER as a prototype nuclear receptor that primarily functions as a transcription factor. In this chapter, we will first describe the conserved domain architecture of ER and its regulation through various modifications by diverse intracellular pathways. We w...Continue Reading »
50 pages | 588 engagements |
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» Abstract A case of AVM was presented and surgical details presented and discussed....Continue Reading »
50 pages | 698 engagements |
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» Abstract It is necessary to employ powerful strategies to screen and to identify new genetic loci involved in the regulation of toxicity of environmental toxicants or stresses in nematodes. We here introduced the usefulness of transcriptomic analysis, proteomic analysis, forward genetics, and reverse genetics in screening and in identifying new genetic loci involved in the regulation of toxicity o...Continue Reading »
50 pages | 480 engagements |
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» Abstract Aim: To identify the genetic aetiology of a distinct leukoencephalopathy causing acute neurological regression in infancy with apparently complete clinical recovery. Methods: We performed trio whole genome sequencing (WGS) to determine the genetic basis of the disorder. Mitochondrial function analysis in cultured patient fibroblasts was undertaken to confirm the pathogenicity of candidate...Continue Reading »
50 pages | 492 engagements |
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» Abstract Metabolomic profiling is an emerging technology in the clinical setting with immediate diagnostic potential for the population of patients with Inborn Errors of Metabolism. We present the metabolomics profile of two ABAT deficiency patients both pre and posttreatment with flumazenil. ABAT deficiency, also known as GABA transaminase deficiency, is caused by recessive mutations in the gene ...Continue Reading »
50 pages | 611 engagements |
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» Abstract Niemann Pick type C disease (NPC) is a neurovisceral lysosomal storage disorder with a heterogeneous phenotype including ataxia, cognitive impairment, impairment of vertical saccades, and psychiatric symptoms, among many others. Based on clinical, genetic, and biomarker findings, recent guidelines put forward a screening for atypical and oligosymptomatic forms of NPC in clinical niches wi...Continue Reading »
50 pages | 573 engagements |
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» Abstract Sir George Beatson proposed a connection between breast cancer and ovary more than a century ago. It took several decades to the discovery of hormone estrogen and a few more decades when Elwood Jensen announced the discovery of estrogen receptor. His work led to our understanding of how hormones control target gene transcription via their receptors. Several laboratories made major contrib...Continue Reading »
50 pages | 558 engagements |